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. 2021 Dec 20;12:759040. doi: 10.3389/fphar.2021.759040

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Copyright © 2021 Liu, Wang, Li, Hu, Xu, Wu, Bai, Ping, Lan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methyl gallate is active for cells from healthy humans or patients with gout. (A,B) ELISA of IL-1β (A) or TNF-α (B) levels in the supernatants from PBMCs stimulated with LPS and ATP in the presence of concentrations of MG (10 and 50 μM). (C) Caspase-1 activity in human PBMCs following LPS + ATP in the presence of MG (10 and 50 μM). (D,E) ELISA of IL-1β (D) and TNF-α (E) in supernatants from SFCs isolated from an individual with gout, treated with MG (50 μM) for 20 h. MG: methyl gallate, Veh: Vehicle, Con: Control. The data are expressed as mean ± S.D. (n = 6) of PBMCs from three healthy donors and the SFCs isolated from two patients were analyzed. Statistical differences were calculated by single-factor ANOVA with Tukey HSD test (A,B), or 2-way ANOVA (C) with post hoc Sidak test for multiple comparisons, or unpaired Student’s t-test (D,E). ^* p < 0.05, ^*** p < 0.001.