TABLE 1.

The effects of methyl gallate on serum and urinary levels of uric acid and creatinine, as well as FEUA and BUN in PO-induced HN mice.

Group	Dose (mg/kg)	SUA (mg/dl)	SCr (mg/dl)	UUA (mg/dl)	UCr (mg/dl)	BUN (mg/dl)	FEUA
Control	PBS	2.45 ± 0.51	0.87 ± 0.08	43.56 ± 4.93	29.45 ± 3.51	30.20 ± 2.83	54.27 ± 11.25
Vehicle	PBS	5.89 ± 0.77##	2.35 ± 0.48##	30.68 ± 4.26##	30.83 ± 2.66	51.07 ± 6.87###	40.74 ± 12.22##
AL	5	3.36 ± 0.12**	1.68 ± 0.12**	34.26 ± 3.55	30.43 ± 3.88	42.35 ± 3.22*	57.38 ± 11.09**
MG	20	4.26 ± 0.53*	1.78 ± 0.21*	36.84 ± 4.83*	27.08 ± 3.04	40.02 ± 4.06**	57.57 ± 11.03**
—	40	3.18 ± 0.58**	1.44 ± 0.13***	40.55 ± 5.12**	26.44 ± 4.29*	36.82 ± 4.47***	72.22 ± 17.81***

Uric acid, creatinine and urea nitrogen in serum and urine were detected by kits. Al: allopurinol. MG: methyl gallate. Values are expressed as means ± S.D. (n = 10). Statistical differences were calculated by single-factor ANOVA with Tukey HSD test. Compared with control: ^# p < 0.05, ^## p < 0.01, ^### p < 0.001; Compared with vehicle: ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001.