TABLE 2.
The effects of methyl gallate on serum and urinary levels of uric acid and creatinine, as well as FEUA and BUN in PO-induced wt and NLRP3 −/− HN mice.
| Group | Dose (mg/kg) | SUA (mg/dl) | SCr (mg/dl) | UUA (mg/dl) | UCr (mg/dl) | BUN (mg/dl) | FEUA |
|---|---|---|---|---|---|---|---|
| WT | PBS | 5.24 ± 0.83 | 2.63 ± 0.32 | 31.32 ± 3.89 | 32.15 ± 3.71 | 49.52 ± 5.86 | 39.68 ± 8.02 |
| WT + MG | 40 | 2.67 ± 0.54*** | 0.85 ± 0.12*** | 45.63 ± 5.32** | 27.20 ± 3.95* | 31.45 ± 4.06*** | 53.66 ± 9.87*** |
| NLRP3 −/− | PBS | 2.45 ± 0.44*** | 0.83 ± 0.09*** | 44.23 ± 3.87** | 30.15 ± 4.80 | 32.98 ± 3.85*** | 55.07 ± 10.14*** |
| NLRP3 −/− +MG | 40 | 2.29 ± 0.36 a | 0.79 ± 0.11 a | 41.04 ± 4.62 a | 29.03 ± 3.24 a | 33.05 ± 4.19 a | 54.08 ± 9.33 a |
Uric acid, creatinine and urea nitrogen in serum and urine were detected by kits. MG: methyl gallate. Values are expressed as means ± S.D. (n = 10) Statistical differences were calculated by single-factor ANOVA with Tukey HSD test. Compared with WT: * p < 0.05, ** p < 0.01, *** p < 0.001.
a
there was no significant difference compared to NLRP3 −/− group.