Table 3.
Changes in vascular atherosclerosis marker after 3 months of anti-thyroid treatment in PTU and methimazole groups.
| Research Parameter | PTU | Methimazole | pβ Value (Overall) | |
|---|---|---|---|---|
| ICAM-1 (ng/mL) a | Baseline | 201.4 (61.3) | 158.8 (73.0) | 0.21 |
| After 1 month of treatment | 192.2 (68.1) | 162.4 (83.8) | ||
| After 3 months of treatment | 141.6 (58.4) | 136.5 (63.0) | ||
| pα value | 0.001 c | 0.31 | ||
| VCAM-1 (ng/mL) b | Baseline | 837 (707–977) | 725 (565–904) | 0.60 |
| After 1 month of treatment | 744 (622–877) | 614 (457–794) | ||
| After 3 months of treatment | 510 (402–630) | 472 (367–590) | ||
| pα value | <0.001 c | 0.001 c | ||
| E-selectin (ng/mL) b | Baseline | 32.1 (24.1–42.7) | 37.4 (30.5–45.9) | 0.67 |
| After 1 month of treatment | 33.2 (25.8–42.7) | 38.5 (33.5–44.2) | ||
| After 3 months of treatment | 28.2 (21.6–36.8) | 35.2 (29.1–42.6) | ||
| pα value | 0.045 c | 0.27 | ||
| Left PWV (m/s) a | Baseline | 6.57 (1.80) | 6.52 (1.50) | 0.22 |
| After 1 month of treatment | 5.68 (1.28) | 6.90 (1.23) | ||
| After 3 months of treatment | 5.96 (1.65) | 6.65 (1.11) | ||
| pα value | 0.15 | 0.82 | ||
| Right PWV (m/s) b | Baseline | 5.74 (5.12–6.43) | 6.31 (5.21–7.64) | 0.91 |
| After 1 month of treatment | 5.72 (5.0–6.55) | 6.13 (5.64–6.66) | ||
| After 3 months of treatment | 5.74 (4.95–6.67) | 6.09 (5.42–6.83) | ||
| pα value | 0.99 | 0.89 | ||
| Left cIMT (μm) b | Baseline | 473.1 (47.4) | 509.4 (75.4) | 0.80 |
| After 1 month of treatment | 477.8 (98.1) | 490.8 (56.4) | ||
| After 3 months of treatment | 468.9 (92.6) | 493.6 (81.3) | ||
| pα value | 0.95 | 0.77 | ||
| Right cIMT (μm) a | Baseline | 495.9 (112.3) | 463.8 (55.3) | 0.35 |
| After 1 month of treatment | 461.5 (82.6) | 478.6 (55.5) | ||
| After 3 months of treatment | 461.2 (95.1) | 445.7 (64.8) | ||
| pα value | 0.50 | 0.30 | ||
pα value for comparison before and after treatment. Repeated ANOVA test.
pβ value for comparison between PTU and methimazole groups. General linear model test.
a
Data presented as mean (SD).
b
Data presented as geometric mean (CI 95%).
c
p-value < 0.05.
ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1; PWV, pulse wave velocity; cIMT, carotid intima media thickness; SD, standard deviation; CI, confidence interval.