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. 2021 Dec 20;12:799444. doi: 10.3389/fphar.2021.799444

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Copyright © 2021 Mahmoud, Rezq, Alsemeh, Abdelfattah, El-Shazly, Daoud, El Raey and Sobeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microscopic representative images of the sciatic nerve transverse sections from the different studied groups (A) control group; (B) sham group (C) CCI group; (D) CCI + pregabalin, (E) CCI + P. perfoliatus extract (200 mg/kg, p.o) (F) CCI + P. perfoliatus extract (400 mg/kg, p.o). Arrow, bifid arrow, arrowhead, star, and circle illustrate axoplasm, area of dissolved myelin, Schwann cells nuclei, wide separation between the nerve fibers, and degenerated nerve fibers, respectively. (bc) blood vessel, and (bc*) dilated blood vessel. Scale bar, 50 μm x400.