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. 2021 Dec 20;12:799444. doi: 10.3389/fphar.2021.799444

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Copyright © 2021 Mahmoud, Rezq, Alsemeh, Abdelfattah, El-Shazly, Daoud, El Raey and Sobeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microscopic images of brainstem tissues from the different studied groups (A) control group (B) sham group; (C) CCI group (D) pregabalin group; (E) P. perfoliatus extract (200 mg/kg, p.o.) (F) P. perfoliatus extract (400 mg/kg, p.o.). Arrow, arrowhead, bifid arrow, wavy arrow, and (*) represent normal neurons with flame elongated dark nuclei, neurons with dark stained nuclei and vacuolated cytoplasm, perineural glial cell nuclei, and neuropil respectively. (bc) normal blood capillary, (*bc) dilated blood capillary, (lg) lightly stained glial cell nuclei, (dg) deeply stained glial cell nuclei. Scale bar, 50 μm x400.