Table 1.
Liver Parameters Affected by PFOA Hepatotoxicity for the Control, PFOA Treatment, and PFOA + VC Treatment Sample Groups.
| Parameters | Control | PFOA | VC + PFOA |
|---|---|---|---|
| Body mass (g) | 45.65 ± 2.06 | 44.83 ± 2.16 | 43.23 ± 3.72 |
| Liver mass (g) | 1.56 ± 0.12 | 3.71 ± 0.18a | 2.35 ± 0.24b |
| Liver index (%) (liver/body weight × 100%) | 3.67 ± 0.21 | 8.9 ± 0.4a | 5.73 ± 0.4b |
| Fasting blood glucose (mmol/L) | 4.7 ± 0.5 | 6.4 ± 1.2 | 4.8 ± 0.8 |
| Total cholesterol (mmol/L) | 3.11 ± 0.15 | 6.6 ± 0.14a | 3.25 ± 0.26b |
| Triglyceride (mmol/L) | 0.68 ± 0.06 | 1.07 ± 0.25a | 0.74 ± 0.05b |
| Alanine aminotransferase (U/L) | 8.71 ± 0.76 | 17.26 ± 1.18a | 11.48 ± 0.45b |
| Aspartate aminotransferase (U/L) | 12.67 ± 1.93 | 29.28 ± 1.52a | 19.02 ± 1.38b |
| Low density lipoprotein (mmol/L) | 0.22 ± 0.03 | 0.35 ± 0.05 | 0.15 ± 0.05b |
| High density lipoprotein (mmol/L) | 7.99 ± 0.86 | 3.24 ± 0.72a | 4.94 ± 0.24b |
| Hepatic lipase (μg/mL) | 126.16 ± 15.82 | 129.85 ± 21.9 | 161.93 ± 6.97b |
Note: Paired Student’s t test (GraphPad Prism 3.02); aP＜0.05 vs control; bP＜0.05 vs PFOA.