Table 2.
Data summarizing the effect of Vitamin C on PFOA-induced gene expression.
| Gene symbol | Gene name | PFOA/Ctrl (up/down) | VC + PFOA/PFOA (up/down) | change |
|---|---|---|---|---|
| Ankrd11 | ankyrin repeat domain 11 | down | up | down-up |
| Ankrd23 | ankyrin repeat domain 23 | down | up | down-up |
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | down | up | down-up |
| Arhgap45 | Rho GTPase activating protein 45 | down | up | down-up |
| B3gat2 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) | down | up | down-up |
| Brwd1 | bromodomain and WD repeat domain containing 1 | down | up | down-up |
| Cbx6 | chromobox 6 | down | up | down-up |
| Ccm2l | cerebral cavernous malformation 2-like | down | up | down-up |
| Cep152 | centrosomal protein 152 | down | up | down-up |
| Cep250 | centrosomal protein 250 | down | up | down-up |
| Chd7 | chromodomain helicase DNA binding protein 7 | down | up | down-up |
| Cldn2 | claudin 2 | up | down | up-down |
| Col11a2 | collagen, type XI, alpha 2 | down | up | down-up |
| Ctsc | cathepsin C | up | down | up-down |
| Cux2 | cut-like homeobox 2 | down | up | down-up |
| Cwc22 | CWC22 spliceosome-associated protein | down | up | down-up |
| Cyp2j9 | cytochrome P450, family 2, subfamily j, polypeptide 9 | down | up | down-up |
| Dnajc12 | DnaJ heat shock protein family (Hsp40) member C12 | up | down | up-down |
| Doc2g | double C2, gamma | down | up | down-up |
| Eno3 | enolase 3, beta muscle | down | up | down-up |
| Fnbp4 | formin binding protein 4 | down | up | down-up |
| Gabbr1 | gamma-aminobutyric acid (GABA) B receptor, 1 | down | up | down-up |
| Gk | glycerol kinase | up | down | up-down |
| Golgb1 | golgi autoantigen, golgin subfamily b, macrogolgin 1 | down | up | down-up |
| Gstp2 | glutathione S-transferase, pi 2 | down | up | down-up |
| Gtf2ird2 | GTF2I repeat domain containing 2 | down | up | down-up |
| Hspd1-ps3 | heat shock protein 1 (chaperonin), pseudogene 3 | up | down | up-down |
| Ifi47 | interferon gamma inducible protein 47 | up | down | up-down |
| Ifngr2 | interferon gamma receptor 2 | up | down | up-down |
| Insl6 | insulin-like 6 | up | down | up-down |
| Itm2c | integral membrane protein 2C | up | down | up-down |
| Kcnq1ot1 | KCNQ1 overlapping transcript 1 | down | up | down-up |
| Kdm2a | lysine (K)-specific demethylase 2A | down | up | down-up |
| Kmt2a | lysine (K)-specific methyltransferase 2A | down | up | down-up |
| Lrch3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | down | up | down-up |
| Macf1 | microtubule-actin crosslinking factor 1 | down | up | down-up |
| Malat1 | metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) | down | up | down-up |
| Mapk8ip3 | mitogen-activated protein kinase 8 interacting protein 3 | down | up | down-up |
| Mdn1 | midasin AAA ATPase 1 | down | up | down-up |
| Mfsd2b | major facilitator superfamily domain containing 2B | down | up | down-up |
| Mir99ahg | Mir99a and Mirlet7c-1 host gene (non-protein coding) | down | up | down-up |
| Morc2a | microrchidia 2A | down | up | down-up |
| Mprip | myosin phosphatase Rho interacting protein | down | up | down-up |
| mt-Rnr1 | mitochondrially encoded 12S rRNA | down | up | down-up |
| mt-Rnr2 | mitochondrially encoded 16S rRNA | down | up | down-up |
| mt-Ti | mitochondrially encoded tRNA isoleucine | down | up | down-up |
| Muc6 | mucin 6, gastric | down | up | down-up |
| Mup18 | major urinary protein 18 | up | down | up-down |
| Nbeal2 | neurobeachin-like 2 | down | up | down-up |
| Ncoa3 | nuclear receptor coactivator 3 | down | up | down-up |
| Ncoa4 | nuclear receptor coactivator 4 | up | down | up-down |
| Oaz1-ps | ornithine decarboxylase antizyme 1, pseudogene | up | down | up-down |
| Ovgp1 | oviductal glycoprotein 1 | down | up | down-up |
| Pakap | paralemmin A kinase anchor protein | down | up | down-up |
| Pan2 | PAN2 poly(A) specific ribonuclease subunit | down | up | down-up |
| Paxbp1 | PAX3 and PAX7 binding protein 1 | down | up | down-up |
| Pde4c | phosphodiesterase 4C, cAMP specific | down | up | down-up |
| Pgam1-ps2 | phosphoglycerate mutase 1, pseudogene 2 | up | down | up-down |
| Pgk1-rs7 | phosphoglycerate kinase-1, related sequence-7 | up | down | up-down |
| Ptdss1 | phosphatidylserine synthase 1 | up | down | up-down |
| Rapgef4os2 | Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 2 | down | up | down-up |
| Rbm5 | RNA binding motif protein 5 | down | up | down-up |
| Rmrp | RNA component of mitochondrial RNAase P | down | up | down-up |
| Rn7s1 | 7S RNA 1 | down | up | down-up |
| Rn7s2 | 7S RNA 2 | down | up | down-up |
| Rn7sk | RNA, 7SK, nuclear | down | up | down-up |
| Rpl28-ps3 | ribosomal protein L28, pseudogene 3 | up | down | up-down |
| Rpl31-ps9 | ribosomal protein L31, pseudogene 9 | up | down | up-down |
| Safb2 | scaffold attachment factor B2 | down | up | down-up |
| Scarf1 | scavenger receptor class F, member 1 | down | up | down-up |
| Sept2 | septin 2 | up | down | up-down |
| Serpina3f | serine (or cysteine) peptidase inhibitor, clade A, member 3F | up | down | up-down |
| Serping1 | serine (or cysteine) peptidase inhibitor, clade G, member 1 | up | down | up-down |
| Setd4 | SET domain containing 4 | down | up | down-up |
| Sfswap | splicing factor SWAP | down | up | down-up |
| Simc1 | SUMO-interacting motifs containing 1 | down | up | down-up |
| Slc25a51 | solute carrier family 25, member 51 | down | up | down-up |
| Taf1a | TATA-box binding protein associated factor, RNA polymerase I, A | down | up | down-up |
| Tnrc6a | trinucleotide repeat containing 6a | down | up | down-up |
| Tpd52 | tumor protein D52 | up | down | up-down |
| Trub2 | TruB pseudouridine (psi) synthase family member 2 | up | down | up-down |
| Tsku | tsukushi, small leucine rich proteoglycan | down | up | down-up |
| Txnrd1 | thioredoxin reductase 1 | up | down | up-down |
| Ugt3a1 | UDP glycosyltransferases 3 family, polypeptide A1 | up | down | up-down |
| Ushbp1 | USH1 protein network component harmonin binding protein 1 | down | up | down-up |
| Zcchc7 | zinc finger, CCHC domain containing 7 | down | up | down-up |
| Zranb1 | zinc finger, RAN-binding domain containing 1 | down | up | down-up |