Table 3.
Summary of Metabolic Pathways for Vitamin C Associated with PFOA-Induced Toxicity.
| Pathway | number of metabolites | p-value | metabolites |
|---|---|---|---|
| Metabolism of xenobiotics by cytochrome P450 | 4 | 0.0035 | Thiodiacetic acid, (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene, (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene, (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene |
| ABC transporters | 4 | 0.037 | Glutathione, Raffinose, Maltotriose, Isomaltotriose |
| Inflammatory mediator regulation of TRP channels | 2 | 0.025 | 1,8-Cineole, Phorbol |
| Linoleic acid metabolism | 2 | 0.0087 | 13-OxoODE, 9-OxoODE |
| Renal cell carcinoma | 1 | 0.014 | (S)-Malate |