TABLE 2.
The characteristics of DILI.
| Newborns (n = 77) | Children (n = 261) | p-value | |
|---|---|---|---|
| Type (based on R a ratio) | |||
| Hepatocellular | 7 (9.1) | 155 (59.4) | |
| Cholestatic | 6 (7.8) | 74 (28.4) | |
| Mixed | 64 (83.1) | 32 (12.2) | |
| <0.001 | |||
| Peak level of laboratory findings | |||
| ALT (U/L) | 910 (226–2,051) | 624 (201–10,266) | 0.412 |
| ALP(U/L) | 411 (252–2,045) | 361 (250–1,888) | 0.372 |
| RUCAM score, mean (median) | 2.70 (3) | 2.54 (2) | <0.001 |
| Highly probable | 2 (2.6) | 8 (3.0) | |
| Probable | 41 (53.2) | 167 (64.0) | |
| Possible | 34 (44.2) | 86 (33.0) | |
| 0.202 | |||
| Number of drugs used during hospitalization | 23 ± 14.0 | 26 ± 14.0 | 0.124 |
a
R= (ALT value/ALT ULN)/(ALP value/ALP ULN). R > 5 = hepatocellular, R < 2 = cholestatic, R between 2 and 5 = mixed.
Values are presented as number (%) or median (range) or Mean ± SD.