TABLE 3.

Drug combinations related to CYP.

	Newborns	Children
CYP1A2	Omeprazole + Phenobarbital Sodium (4); Erythromycin + Phenobarbital Sodium (2); Omeprazole + Erythromycin (2); Omeprazole + Caffeine (1) Omeprazole + Lidocaine (1); Lidocaine + Erythromycin (1).	Omeprazole + Phenobarbital Sodium (4); Erythromycin + Phenobarbital Sodium (2); Omeprazole + Erythromycin (2); Omeprazole + Caffeine (1); Lidocaine + Erythromycin (1).
CYP2C9	Phenobarbital Sodium + Ibuprofen (1); Phenobarbital Sodium + Paracetamol (1); Paracetamol + Ibuprofen (1).	Ibuprofen + Furosemide (48); Paracetamol + Furosemide (26); Paracetamol + Furosemide (15); Phenobarbital Sodium + Furosemide (13); Paracetamol + Ibuprofen + Furosemide (5); Phenobarbital Sodium + Ibuprofen (3); Phenobarbital Sodium + Ibuprofen + Furosemide (2); Indometacin + Furosemide (1); Furosemide + Warfarin (1); Indometacin + Furosemide + Ibuprofen (1).
CYP2C19	Omeprazole + Sodium Valproate (1)	Diazepam + Omeprazole (40); Sodium Valproate + Diazepam (9); Voriconazole + Omeprazole (7); Omeprazole + Sodium Valproate (7); Diazepam + Voriconazole (6); Omeprazole + Voriconazole (4); Sodium Valproate + Diazepam + Omeprazole (3); Sodium Valproate + Voriconazole (1).
CYP3A4	Omeprazole + Budesonide (13); Dexamethasone + Midazolam (8); Midazolam + Sildenafil (8); Omeprazole + Midazolam (7); Omeprazole + Dexamethasone + Fentanyl + Midazolam (5); Budesonide + Dexamethasone (5); Budesonide + Midazolam (5); Fentanyl + Midazolam (4); Fluconazole + Caffeine (4); Spironolactone + Midazolam + Sildenafil (4); Omeprazole + Dexamethasone + Midazolam (2); Omeprazole + Fentanyl + Midazolam (2); Budesonide + Spironolactone + Sildenafil (2); Diazepam + Midazolam (2); Erythromycin + Midazolam (2); Methylprednisolone + Midazolam (2); Lidocaine + Midazolam (2); Spironolactone + Midazolam (2); Azithromycin + Caffeine (1).	Fentanyl + Midazolam (54); Omeprazole + Budesonide (32); Omeprazole + Methylprednisolone (25); Budesonide + Methylprednisolone (23); Fentanyl + Methylprednisolone + Midazolam (23); Omeprazole + Fentanyl + Midazolam (12); Budesonide + Salbutamol (11); Diazepam + Midazolam (11); Omeprazole + Dexamethasone (10); Omeprazole + Diazepam (10); Omeprazole + Midazolam (10); Budesonide + Midazolam (10); Sodium Valproate + Midazolam (9); Budesonide + Fentanyl + Midazolam (9); Dexamethasone + Voriconazole (9);Paracetamol + Methylprednisolone (9); Diazepam + Fentanyl + Midazolam (8); Omeprazole + Dexamethasone + Fentanyl + Midazolam (7); Budesonide + Spironolactone (7); Ondansetron + Vindesine + Dexamethasone (6); Sodium Valproate + Diazepam (6); Diazepam + Methylprednisolone (6); Vindesine + Dexamethasone (6); Omeprazole + Diazepam + Fentanyl + Midazolam (5); Omeprazole + Fentanyl + Methylprednisolone + Midazolam (5); Omeprazole + Methylprednisolone + Midazolam (5); Budesonide + nifedipine (5);Digoxin + Spironolactone (5); Dexamethasone + Midazolam (5); Lidocaine + Midazolam (5).