Figure 5.

AHV tuning in the RSC depends on sensory transduction in the vestibular organs

(A) Experimental configuration. (Left) Mouse is rotated 180° back and forth in CW and CCW directions and at different rotation speeds. (Middle) Same experiment repeated in the dark. (Right) Mouse is stationary, but now the wall of the arena with visual cues is rotated to simulate the visual flow experienced when the mouse is rotating.

(B) (Top row) Responses of an example cell for a whole session (deconvolved DF/F events) under the three different conditions indicated in (A). Trials are sorted by velocity (see color code in Figure 3A). White background indicates that the mouse is rotating, and a gray background indicates that the mouse is stationary. (Bottom row) angular velocity tuning curves showing average rate (± SEM) as a function of rotation velocity.

(C) Response (average rate ± SEM) of all cells classified as CW (top row) or CCW selective (bottom row) and separated by rotation speed. Total numbers of recorded cells are as follows: rotations in light = 4,928 cells from 10 mice, rotation darkness = 4,963 cells from 10 mice, and visual flow only = 3,192 cells from 7 mice).

(D) Pie charts show the average percentage of classified cells using the LNP model in each of the three conditions indicated in (A) for p < 0.05.

(E) The AHV decoding error (average ± SEM) as a function of rotation speed using the LNP model.