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. 2021 Dec 17;9(12):23259671211062929. doi: 10.1177/23259671211062929

TABLE 1.

Stages of Tendon Healing 34 a

Inflammatory Stage Proliferative Stage Remodeling: Consolidation Stage Remodeling: Maturation Stage
  • 24-72 h

  • Erythrocytes and neutrophils

  • Phagocytosis

  • Vasoactive and chemotactic factors for vascular permeability

  • Initiation of angiogenesis

  • Stimulation of tenocyte proliferation and migration

  • Initiation of type 3 collagen synthesis

  • 3 d-6 wk

  • Type 3 collagen synthesis (peak)

  • High water concentration

  • High GAG concentration

  • 6-10 wk

  • Decreased cellularity (collagen, GAG)

  • Increased fibrous repair

  • High tenocyte metabolism

  • Tenocyte and collagen fibers align parallel to stress

  • 10 wk-1 y

  • Transition to scar-like tendon

  • Decreased tenocyte metabolism

  • Decreased vascularity

a GAG, glycosaminoglycan.