Table 2.

Recommended dosage regimens of concentrates of von Willebrand factor/factor VIII or von Willebrand factor only in patients with von Willebrand disease undergoing surgical prophylaxis.

Indication	Dosage regimen	Target plasma VWF:RCo/FVIII:C level*
Major surgery	40–60 IU/kg once daily until wound healing is complete	50–100 IU/dl; maintain levels for 5–10 days
Minor surgery	30–50 IU/kg once daily (may require for only 1–3 days)	>30 IU/dl
Dental extraction or other invasive procedures	20–30 IU/kg (usually a single dose prior to procedure)	>30 IU/dl for >12 h

^*These dosages are indicated for patients with von Willebrand disease with reduced factor VIII activity/von Willebrand factor risotecin cofactor levels (<10 IU/dl).