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. 2021 Dec 22;14:17562848211065329. doi: 10.1177/17562848211065329

Table 2.

List of studies reporting dose-optimization in IBD.11–90

Authors, ref Year Country Study design Data collection Disease Sample size Medication Follow-up year % Dose escalation % Efficacy
Afif et al. 11 2009 USA Observational Medical records UC 20 ADA 0.46 35 NA
Amiot et al. 12 2016 France Prospective 41 centres UC 121 VDZ 1 up to 47 NA
Armuzzi et al. 13 2013 Italy Retrospective 22 centres UC 88 ADA 1.29 35.2 NA
Baert et al. 14 2014 Belgium Retrospective Medical records UC 73 ADA 1.69 30.1 NA
Baki et al. 15 2015 Germany Retrospective Medical records UC 37/54 ADA/IFX 2.25 45.9/48.1 NA
Black et al. 16 2015 England Retrospective Data base UC 191 ADA NR 43.5 NA
Cesarini et al. 17 2014 Europe Retrospective Data base UC 41 IFX 1 All at LOR 92
Christensen et al. 18 2015 Denmark Retrospective Medical records UC 33 ADA 0.62 21.2 NA
Dumitrescu et al. 19 2015 France Retrospective Data base UC 157 IFX 1.8 All at LOR 55
Hussey et al. 20 2016 Ireland Retrospective Data base UC 52 ADA 1 25 NA
Iborra et al. 21 2016 Spain Retrospective Data base ENEIDA UC 263 ADA > 1 35.4 NA
Null et al. 22 2017 USA Retrospective Data base UC 295 ADA/IFX 1 50/37.3 NA
Patel et al. 23 2017 USA Retrospective Claims database UC 1699 Anti-TNF 3 16/44 NA
Rostholder et al. 24 2012 USA Retrospective Medical records UC 56 IFX 3.17 54 19
Sandborn et al. 25 2016 USA Retrospective Chart reviews UC 804 ADA/IFX 1.5 5/11 NA
Taxonera et al. 26 2017 Spain Retrospective 14 centres UC 79 IFX 1.25 All at LOR 58
Yamada et al. 27 2014 Japan Retrospective Medical records UC 33 IFX 3 70.8 94
Aguas et al. 28 2012 Spain Prospective Medical records CD 29 ADA 1 17.2 NA
Amiot et al. 29 2015 France Prospective Medical records CD 59 IFX 12 13 NA
Baert et al. 30 2013 Belgium Prospective Medical records CD 720 ADA 1.2 68 67
Bhalme et al. 31 2013 England Retrospective Medical records CD 54/76 ADA/IFX 7 20/6 NA
Bortlik et al. 32 2013 Hungary Retrospective Medical records CD 84 IFX 2 7 NA
Bouguen et al. 33 2015 France Prospective Medical records CD 42 ADA 0.5 All 85
Bultman et al. 34 2012 Netherlands Prospective Medical records CD 122 ADA 1.8 38 43
Castano-Milla et al. 35 2015 Spain Retrospective Medical records CD 46 ADA 1 20 33
Caviglia et al. 36 2007 Italy Retrospective Medical records CD 40 IFX 1.2 9 NA
Chaparro et al. 37 2012 Spain Prospective Medical records CD 33 IFX 3 40 NA
Chaparro et al. 38 2011 Spain Prospective Data base CD 15 IFX 0.5 17 NA
Echarri et al. 39 2015 Spain Prospective Medical records CD 68 ADA 2 18 75
Fortea-Ormaechea et al. 40 2011 Spain Prospective Medical records CD 174 ADA 1.5 33 NA
Gagniere et al. 41 2015 France Prospective 4 centres CD 61 IFX 1.2 52 NA
Gonzalez-Lama et al. 42 2008 Spain Retrospective Medical records CD 169 IFX 0.5 13 NA
Ho et al. 43 2009 England Retrospective Medical records CD 98 ADA 2 24–55 NA
Juillerat et al. 44 2015 France Retrospective Medical records CD 267 IFX 5 31 NA
Karmiris et al. 45 2009 Belgium Retrospective Medical records CD 168 ADA 2 60 76
Katz et al. 46 2012 Multinational Retrospective Medical records CD 168 IFX 1 32 NA
Kiss et al. 47 2011 Hungary Prospective Medical records CD 201 ADA 1 16 NA
Kopylov et al. 48 2011 Multinational Prospective Medical records CD 94 IFX 1 All NA
Lees et al. 49 2009 Scotland Prospective Medical records CD 202 ADA/IFX 2.4 53 NA
Lindsay et al. 50 2013 England Retrospective Medical records CD 380 IFX 2 5 NA
Lopez Palacios et al. 51 2008 Spain Retrospective Medical records CD 22 ADA 4 27 67
Magro et al. 52 2014 Portugal Retrospective Medical records CD 148 IFX 12 19 NA
Molnár et al. 53 2012 Hungary Retrospective Data base CD 61 ADA/IFX 1 62 NA
Ng et al. 54 2009 England Retrospective Medical records CD 34 ADA/IFX 1.5 29 100
Nichita et al. 55 2010 Switzerland Retrospective Medical records CD 55 ADA 3 24 15
Orlando et al. 56 2012 Italy Retrospective Multi centres CD 110 ADA 1.4 9 NA
Oussalah et al. 57 2010 France Prospective Medical records CD 88 IFX 2.5 17 86
Oussalah et al. 58 2009 France Retrospective Medical records CD 53 ADA 3 10–17 NA
Pariente et al. 59 2012 France Retrospective Medical records CD 76 IFX 3.5 51 NA
Peters et al. 60 2014 Netherlands Retrospective Data Base CD 438 ADA 1 40 NA
Peyrin-Biroulet et al. 61 2007 France Retrospective Medical records CD 24 ADA 1 25 NA
Reenaers et al. 62 2012 England Retrospective Medical records CD 207 ADA 6 81 NA
Riis et al. 63 2012 Norway Retrospective Data base CD 83 ADA/IFX1 1 5.3/17 NA
Russo et al. 64 2010 England Retrospective Data base CD 61 ADA 0.7 16 NA
Schnitzler et al. 65 2009 Belgium Retrospective Data base CD 614 IFX 5 49.8 NA
Sprakes et al. 66 2012 England Retrospective Medical records CD 210 IFX 2 2 NA
Sprakes et al. 67 2011 England Retrospective Medical records CD 44 ADA 2 18 NA
Viazis et al. 68 2015 Greece Retrospective Medical records CD 322 ADA/IFX 2.2 24 NA
West et al. 69 2008 Netherlands Retrospective Medical records CD 30 ADA 0.8 27 75
Ehrenberg et al. 70 2020 USA Retrospective Insurance database IBD 2406 IFX 1 39 NA
Ehrenberg et al. 70 2020 USA Retrospective Insurance database IBD 1966 ADA 1 28 NA
Ehrenberg et al. 70 2020 USA Retrospective Insurance database IBD 1745 VDZ 1 23 NA
Ehrenberg et al. 70 2020 USA Retrospective Insurance database IBD 472 UST 1 22 NA
Ehrenberg et al. 70 2020 USA Retrospective Insurance database IBD 154 GOL 1 14 NA
Dignass et al. 71 2020 Germany Retrospective Insurance database UC 125 ADA 3 73 NA
Dignass et al. 71 2020 Germany Retrospective Insurance database UC 47 GOL 3 18.5 NA
Dignass et al. 71 2020 Germany Retrospective Insurance database UC 114 IFX 3 65.3 NA
Church et al. 72 2019 Canada Retrospective Medical records UC 125 IFX 1 42 NA
Cesarini et al. 17 2014 Italy Retrospective Multi centres UC 41 IFX 1 All NA
Kósa et al. 73 2020 Hungary Retrospective Nationwide CD 873 IFX/ADA 1 9/22 NA
Ungar et al. 74 2019 USA Retrospective Medical records IBD 48 IFX 1 ALL NA
Jasurda et al. 75 2020 USA Retrospective Medical records IBD 380 ADA 1 52 NA
Duveau et al. 76 2017 France Retrospective Medical records CD 124 ADA 1 ALL NA
Taxonera et al. 26 2017 Spain Retrospective Medical records UC 184 ADA 1 41 NA
Suzuki et al. 77 2019 Japan Retrospective Medical records CD 203 ADA 1 7 NA
Van de Vondel et al. 78 2018 Belgium Retrospective 10 centres UC 231 ADA 1 56 NA
Shmidt et al. 79 2018 Europe, USA Retrospective Multi centres IBD 788 VDZ 1 12 NA
Vaughn et al. 80 2020 USA Prospective S
+6erum level check		 IBD 192 VDZ 0.5 30 NA
Perry et al. 81 2020 USA Retrospective Medical records UC 90 VDZ 0.5 27 NA
Haider et al. 82 2020 USA Retrospective Medical records CD 143 UST 1.5 19 NA
Fumery et al. 83 2020 France Retrospective Multi centres CD 100 UST 0,7 ALL 61
Kopylov et al. 84 2020 Multinational Retrospective Multi centres CD 142 UST 0.5 ALL 51
Ollech et al. 85 2021 USA Retrospective Multi centres CD 506 UST 1 22 NA
Ma et al. 86 2017 Canada Retrospective Multi centres CD 104 UST 1 16.3 NA
Honap et al. 87 2020 England Retrospective Medical records UC 134 TOF 0.5 14 NA
Sands et al. 88 2020 Multinational Prospective OLE OCTAVE UC 57 TOF 1 ALL 49
Sandborn et al. 89 2007 Multinational Prospective CLASSIC CD 204 ADA 1 43.6 75

ADA, Adalimumab; CD, Crohn’s disease; GOL, Golimumab; IBD, Inflammatory bowel disease; IFX, infliximab; LOR, loss of response; TOF, Tofacitinib; UC, ulcerative colitis; UST, Ustekinumab; VDZ, Vedolizumab.

Dose escalation has been performed either increasing the dose or shortening the administration interval.