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. 2021 Dec 20;12:782190. doi: 10.3389/fneur.2021.782190

Figure 4.

Figure 4

(A) Mice were administered 0.3% cuprizone (CPZ) on days 0–42 and daily EOM SalB treatment on days 35-70. (B,C) EOM SalB (0.3 mg/kg/i.p./day)-treated mice gained significantly more weight than vehicle-treated mice [area under the curve (AUC) analysis of the weights on days 36–70)]. (D) Cuprizone administration significantly decreased the force paw-withdrawal threshold for mechanical stimulation, however, EOM SalB (0.3 mg/kg) treatment showed no significant change compared to vehicle-treated mice. (E) Cuprizone administration significantly decreased the score on the horizontal bar test, however, EOM (0.3 mg/kg) treatment had no significant effect compared to vehicle-treated mice. (D,E) Two-way repeated-measures ANOVA with Bonferroni post-tests (separate analysis for days 0–35 and days 36–56). (C) One-way ANOVA with Bonferroni post-tests. Data presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. n = 6–9 per treatment group. Image in panel (A) created using Biorender.com.