Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 20;12:782190. doi: 10.3389/fneur.2021.782190

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Paton, Robichon, Templeton, Denny, Al Abadey, Luo, Prisinzano, La Flamme and Kivell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

EOM SalB administration changes the number of oligodendrocytes in the corpus callosum of mice administered 0.3% cuprizone (CPZ). (A) Representative images showing DAPI-positive nuclei (blue), SOX10-positive cells identifying all cells within the oligodendrocyte lineage (green) and mature GST-pi-positive mature oligodendrocytes (red) in the region of interest. Scale bar is 100 μm. (B) The number of SOX10-positive cells was not significantly altered following EOM SalB treatment (0.3 mg/kg). (C) EOM SalB administration increased the number of GST-pi-positive oligodendrocyte cells at days 42 and 49 compared to the vehicle-treated control mice. Images were analyzed using Cell Profiler in 3 sections per animal (averaged), n = 5–6 mice per treatment. Unpaired t-test. Data presented as mean ± SEM. *p < 0.05, **p < 0.01, n.s. not significant.