Extended Data Fig. 8 ∣. CSF1 levels control skeletal maintenance and repair.

a, Representative μCT images of day-10 fracture calluses at the time of surgery supplemented with hydrogel containing recombinant CSF1 (5 μg) or PBS as control. b, BMD of day-10 fracture calluses treated with or without rCSF1 (PBS, n = 5; rCSF1, n = 4). c, Total number of SSCs and BCSPs at day 10 assessed by FACS (PBS, n = 4; rCSF1, n = 3). d, Representative μCT reconstructions of femur bones from uninjured wild-type or haplo-insufficient Csf1^KO (Csf1^KO+/−) 15-month-old female and male mice. e, Trabecular BMD (top) and cortical total mineral density (TMD; bottom) of femur bones from female and male wild-type and Csf1^KO mice (n = 4 per genotype and sex). f, Bone parameters quantified by μCT from uninjured 15-month-old wild-type and Csf1^KO female and male mice (n = 4 per genotype and sex). g, Bone parameters quantified by μCT from 21-day fracture calluses of 15-month-old wild-type and Csf1^KO female mice (WT, n = 4; Csf1^KO, n = 7). All comparison of 2-month-old versus 24-month-old groups by two-sided Student’s t-test. Data are mean + s.e.m. For exact P values, see Source Data.