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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Nature. 2021 Aug 11;597(7875):256–262. doi: 10.1038/s41586-021-03795-7

Extended Data Fig. 11 ∣. Graphical abstract of SSC-mediated skeletal ageing.

Extended Data Fig. 11 ∣

Loss of skeletal integrity with age owing to reduced bone formation and increased bone resorption is associated with reduced SSC frequency and activity. The 24-month-old skeleton is characterized by increased bone loss, impaired regeneration and lineage skewing of the SSC lineage towards osteoclast-supportive stroma. Skeletal regeneration can be rejuvenated by simultaneous application of recombinant BMP2 and a low dose of an antibody blocking the action of CSF1.