Table.
Top Up- and Downregulated Genes (P < 10−3) after CRISPRa of ST8SIA1 in HeLa Cells.
| Gene | Description | Fold Change (log2) | P Value | q Value |
|---|---|---|---|---|
| Upregulated genes | ||||
| ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 9.5 | 1.7E-20 | 2.3E-16 |
| ABCA1 a | ATP binding cassette subfamily A member 1 | 1.6 | 4.2E-05 | 1.5E-02 |
| APCDD1L | APC downregulated 1 like | 1.5 | 4.9E-08 | 2.3E-04 |
| HLA-DMB | Major histocompatibility complex, class II, DM beta | 1.3 | 3.3E-05 | 1.4E-02 |
| CA11 | Carbonic anhydrase 11 | 1.3 | 1.6E-05 | 8.9E-03 |
| LPAR5 | Lysophosphatidic acid receptor 5 | 1.2 | 3.5E-07 | 5.7E-04 |
| HLA-DMA | Major histocompatibility complex, class II, DM alpha | 1.2 | 4.2E-07 | 5.7E-04 |
| ANGPTL2 | Angiopoietin-like 2 | 1.1 | 1.8E-04 | 3.9E-02 |
| Downregulated genes | ||||
| PKD1L1 | Polycystin 1 like 1, transient receptor potential channel interacting | −1.8 | 5.7E-05 | 1.9E-02 |
| MALAT1 | Metastasis-associated lung adenocarcinoma transcript 1 | −0.7 | 5.9E-09 | 4.0E-05 |
| ENC1 | Ectodermal-neural cortex 1 | −0.5 | 5.2E-05 | 1.8E-02 |
| MXRA5 | Matrix remodeling associated 5 | −0.4 | 2.7E-05 | 1.3E-02 |
| ND5 | Mitochondrially encoded NADH/ubiquinone oxidoreductase core subunit 5 | −0.4 | 1.1E-05 | 6.8E-03 |
| AMH | Anti-Mullerian hormone | −0.4 | 3.9E-04 | 6.4E-02 |
| ND1 | Mitochondrially encoded NADH/ubiquinone oxidoreductase core subunit 1 | −0.4 | 1.1E-07 | 3.6E-04 |
| ZNF469 | Zinc finger protein 469 | −0.3 | 1.2E-04 | 3.1E-02 |
a
Periodontitis risk gene (Teumer et al. 2013), highlighted in bold letters.