Figure 3.

Effect of the peptides on gene expression of proteolytic enzymes in synovium. Synovial explants were treated for 48 hours with the peptides and gene expression of different proteolytic enzymes was measured by quantitative polymerase chain reaction (qPCR). Each gene expression measurement was first normalised to the BestKeeper Index (BKI). Each condition is relative to the carrier control, to which is compared; each donor is represented by a different symbol (n = 4 donors in triplicate, one of them in duplicate) and grand mean is represented.