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. 2020 Dec 27;13(2 Suppl):1522S–1529S. doi: 10.1177/1947603520982350

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Representative histological changes in calcified cartilage and subchondral bone. According to the scoring system, (a) the histological image in the sham limb at 8 weeks was grade 0. (b, c, and d) The histological images in the operated limb at 8 weeks in the HS-OA group were grades 1, 2, and 3, respectively. Grade 0 indicates no remarkable histological change; grade 1 indicates increased basophilia and minimal focal marrow change (red triangle); grade 2 indicates mild focal fragmentation of calcified cartilage of the tidemark and thickening of subchondral bone (black triangle); and grade 3 indicates mild to marked fragmentation of calcified cartilage/subchondral bone loss (yellow triangle). For grade definition, see Supplementary Method 2. Scale bar = 500 μm. OA, osteoarthritis; HS, hindlimb suspension.