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. 2021 Dec 20;12:724511. doi: 10.3389/fphar.2021.724511

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Copyright © 2021 Shang, Liu, Li, Pan, Zhou and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A-B) The expression of VDR was observed with a fluorescence microscope after siRNA was introduced into NCM460 cells for 48 h and 72 h (C)The protein levels of VDR, Nrf2, p-Nrf2, HO-1 molecules were detected by western blotting. (D) The mRNA levels of above molecules were detected by RT -PCR. (E–F) Transepithelial resistance (TEER) and FITC-Dextran 4 kDa flux were measured to assess monolayer permeability. (G–J) Quantitative results of VDR and its downstream protein expression. ^$ p < 0.05 compared with the normal group; ^# p < 0.05 vs si-VDR group; ^∗ p < 0.05,^∗∗ p < 0.01 vs si-VDR + LPS group; ^∆ p < 0.05, ^∆∆ p < 0.01, compared with the DEX group. si-VDR: VDR was knocked down in NCM460 cells by siRNA. si-NC: SiRNA negative control group.