Figure 2.

Spinal sPLA₂ inhibition at day 7 after painful nerve root compression abolishes existing sensitivity through day 14. Painful nerve root compression (NRC) significantly decreases withdrawal thresholds from baseline (*p < 0.0001) and relative to corresponding sham thresholds (#p < 0.0002) through day 7. Treatment with the PBS vehicle on day 7 does not alter withdrawal thresholds, which remain significantly lower than baseline (*p < 0.0001) and sham (#p < 0.014) through day 14. But, after intrathecal treatment with the sPLA₂ inhibitor, thresholds are significantly elevated (##p < 0.0004) over thresholds for the vehicle treatment group and return to sham levels as early as day 8 lasting through day 14.