Figure 3.

Intrathecal administration of the sPLA₂ inhibitor reduces cPLA₂ activity in the spinal cord and increases intracellular glutamate concentration after a painful nerve root compression (NRC). (a) Spinal cPLA₂ activity in the vehicle treated group is significantly elevated over (#p = 0.008) sham activity levels at day 14; but, sPLA₂ inhibition after NRC significantly reduces (*p = 0.018) spinal cPLA₂ activity to sham levels. (b) Intracellular glutamate levels in spinal tissues after a painful NRC are significantly lower with vehicle treatment than for NRC with inhibitor treatment (*p = 0.006) and sham (#p = 0.022).