Figure 4.

Spinal sPLA₂ inhibition restores glial transporter expression at day 14 after nerve root injury. (a) Representative blots show spinal glutamate transporter expression for all groups. (b) Spinal GLAST expression with vehicle treatment after a painful root compression (NRC) is higher than levels of expression for sham (#p = 0.027), but inhibitor treatment after NRC significantly reduces (*p = 0.034) GLAST expression to sham levels. Conversely, vehicle treatment significantly downregulates GLT1 compared to sham control levels (#p < 0.0006), but GLT1 protein levels for NRC with inhibitor treatment are significantly (*p <0.009) higher than levels for untreated NRC and are not different from sham.