Figure 5.

At day 14, painful nerve root compression (NRC) increases mGluR5 and GluR1 expression that is reduced with spinal sPLA₂ inhibition. (a) Representative blots show spinal mGluR5, GluR1, and NR1 expression. (b) Spinal sPLA₂ inhibition significantly reduces both mGluR5 (*p < 0.01) and GluR1 (*p < 0.035) expression to sham levels, as compared to expression in vehicle-treated spinal cord. Whereas expression in the vehicle-treated NRC group for both receptors is significantly greater (#p = 0.002 mGluR5; #p = 0.0004 GluR1) than sham expression levels. NR1 expression is not different between any groups.