Figure 6.

Spinal neuronal phenotype distribution and evoked activity at day 14 with a nerve root compression (NRC) are restored to sham levels with spinal sPLA₂ inhibitor treatment at day 7. (a) The proportion of WDR neurons is greatest with for NRC with vehicle treatment and the distribution of LTM, WDR and NS neurons is significantly (#p = 0.027) different from sham and NRC with inhibitor treatment (*p = 0.005). Inhibitor treatment restores the phenotypic distribution to sham levels. (b) Representative voltage tracings from WDR neurons show inhibitor treatment reduces neuronal activity following 1.4 g stimulation as compared to vehicle. (c) sPLA₂ inhibitor treatment significantly reduces evoked activity in all neuronal phenotypes (LTM *p < 0.0005; WDR *p < 0.038; NS *p < 0.029) compared to activity in the NRC with vehicle treatment, with no differences between the inhibitor treated and sham groups. Evoked activity in the vehicle-treated group is also significantly elevated (LTM #p < 0.0007; WDR #p < 0.039; NS #p < 0.015) for all filaments compared to sham for every neuronal phenotype.