Figure 4.

Diffusion tensor imaging analysis from magnetic resonance imagining images including fractional anisotropy (A), axial diffusivity (B), and mean diffusivity (C) with statistical threshold shown whereby Nemo^beKO mice treated with simvastatin (SV) are significantly different in both left (D) and right hemisphere (E) structures including the pyramidal tract, olfactory tubercle, and inferior olivary complex. One-way ANOVA with post-hoc Newman-Keuls multiple comparison tests were performed for each structure of interest for axial diffusivity. N = 8–10 mice/group, *p < 0.05 and **p < 0.01.