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. 2021 Dec 20;12:801741. doi: 10.3389/fendo.2021.801741

Table 1.

Demographic and clinicopathological manifestations.

Variables All (n = 125) Protruding (n = 77) Ulcerative (n = 48) P-value
Gender, n (%) 0.97
Male 81 (64.8%) 50 (64.9%) 31 (64.6%)
Female 44 (35.2%) 27 (35.1%) 17 (35.4%)
Age (yr, mean ± SD) 56.1 ± 11.8 54.9 ± 11.0 58.0 ± 12.7 0.15
BMI (kg/m2, mean ± SD) 24.3 ± 3.0 24.6 ± 3.4 23.9 ± 3.0 0.29
Family history of cancer, n (%) 28 (22.4%) 19 (25.0%) 9 (18.8%) 0.45
Smoking 44 (35.2%) 24 (31.2%) 20 (41.7%) 0.22
Alcohol consumption 43 (34.4%) 27 (35.1%) 16 (33.3%) 0.93
Location, n (%) 0.67
Rectum 94 (75.2%) 61 (79.2%) 33 (68.8%)
Sigmoid colon 11 (8.8%) 6 (7.8%) 5 (10.4%)
Descending colon 5 (4.0%) 2 (2.6%) 3 (6.3%)
Transverse colon 3 (2.4%) 2 (2.6%) 1 (2.1%)
Cecum and ascending colon 12 (9.6%) 6 (7.8%) 6 (12.5%)
Size (cm), median (IQR) 3.0 (2.0, 5.0) 2.5 (1.7, 4.0) 5.0 (3.0, 7.0) <0.001
Grade 0.001
G1 21 (16.8%) 18 (23.4%) 3 (6.25%)
G2 28 (22.4%) 22 (28.6%) 6 (12.5%)
G3 76 (60.8%) 37 (48.1%) 39 (81.3%)
Differentiation 0.001
NET 61 (48.8%) 47 (61.0%) 14 (29.2%)
NEC 64 (51.2%) 30 (39.0%) 34 (70.8%)
Synaptophysin, n (%) 118 (94.4%) 72 (93.5%) 46 (95.8%) >0.99
Chromogranin, n (%) 78 (67.8%) 46 (59.7%) 32 (66.7%) 0.53
CD56, n (%) 0.27
Positive 91 (72.8%) 63 (90.0%) 28 (82.4%)
Negative 13 (10.4%) 7 (10.0%) 6 (17.6%)
Unknown 21 (16.8%) 7 (9.1%) 14 (29.2%)
Ki-67 (%), median (IQR) 40.0% (5.0%, 70.0%) 10.0% (3.0%, 60.0%) 60.0% (27.5%, 80.0%) <0.001
T stage, n (%) 0.006
T1, T2 39 (31.2%) 31 (40.3%) 8 (16.7%)
T3, T4 86 (68.8%) 46 (59.7%) 40 (83.3%)
N stage, n (%) 0.73
N0 20 (16.0%) 13 (16.9%) 7 (14.6%)
N1 105 (84.0%) 64 (83.1%) 41 (85.4%)
M stage, n (%) 0.18
M0 77 (61.6%) 51 (66.2%) 26 (54.2%)
M1 48 (38.4%) 26 (33.8%) 22 (45.8%)
TNM stage, n (%) 0.40
II 15 (12.0%) 10 (13.0%) 5 (10.4%)
III 62 (49.6%) 41 (53.2%) 21 (43.8%)
IV 48 (38.4%) 26 (33.8%) 22 (45.8%)
EMVI, n (%) 0.11
Positive 51 (40.8%) 30 (48.4%) 21 (65.6%)
Negative 43 (34.4%) 32 (51.6%) 11 (34.4%)
Unknown 31 (24.8%) 15 (19.5%) 16 (33.3%)
PNI, n (%) 0.67
Positive 41 (32.8%) 28 (45.2%) 13 (40.6%)
Negative 53 (42.4%) 34 (54.8%) 19 (59.4%)
Unknown 31 (24.8%) 15 (19.5%) 16 (33.3%)
Surgery 101 (80.8%) 66 (85.7%) 35 (72.9%) 0.08
Chemotherapy 94 (75.2%) 56 (72.7%) 38 (79.2%) 0.42
Radiotherapy 21 (16.8%) 10 (13.0%) 11 (22.9%) 0.15

Patients with unknown information were not included in the χ2 -test.

SD, standard deviation; BMI, body mass index; IQR, interquartile range; NET, neuroendocrine tumor; NEC, neuroendocrine carcinoma; EMVI, extramural vascular invasion; PNI, perineural invasion.