Table 3.
Stratification analysis by presence or absence of distant metastasis.
| Variables | Regional NENs | Metastatic NENs | ||||
|---|---|---|---|---|---|---|
| Protruding (n = 51) | Ulcerative (n = 26) | P-value | Protruding (n = 26) | Ulcerative (n = 22) | P-value | |
| Size (cm), median (IQR) | 2.1 (1.5, 3.6) | 4.0 (2.0, 7.5) | 0.002 | 3.0 (2.1, 4.0) | 5.0 (4.0, 6.0) | 0.001 |
| Grade, n (%) | 0.003 | 0.04 | ||||
| G1 and G2 | 28 (54.9%) | 5 (19.2%) | 12 (46.2%) | 4 (18.2%) | ||
| G3 | 23 (45.1%) | 21 (80.8%) | 14 (53.8%) | 18 (81.8%) | ||
| Differentiation, n (%) | 0.008 | 0.03 | ||||
| NET | 32 (62.7%) | 8 (30.8%) | 15 (57.7%) | 6 (27.3%) | ||
| NEC | 19 (37.3%) | 18 (69.2%) | 11 (42.3%) | 16 (72.7%) | ||
| Ki-67 (%), median (IQR) | 5.0% (2.0%, 50.0%) | 65.0% (20.0%, 80.0%) | 0.02 | 25.0% (5.0%, 65.0%) | 60.0% (29.0%, 80.0%) | 0.13 |
| T stage, n (%) | 0.03 | 0.45 | ||||
| T1, T2 | 27 (52.9%) | 7 (26.9%) | 4 (15.4%) | 1 (4.5%) | ||
| T3, T4 | 24 (47.1%) | 19 (73.1%) | 22 (84.6%) | 21 (95.5%) | ||
IQR, interquartile range; NET, neuroendocrine tumor; NEC, neuroendocrine carcinoma; NEN, neuroendocrine neoplasm.