Table 6.
Univariable and multivariable Cox proportional hazards regression analysis for OS.
| Variables | Univariable | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age (> 60 vs ≤ 60) | 2.515 | 1.424-4.443 | 0.001 | 2.055 | 1.025-4.120 | 0.04 |
| Morphology (ulcerative vs protruding) |
3.428 | 1.915-6.137 | <0.001 | 2.280 | 1.123-4.628 | 0.02 |
| Location (colon vs rectum) |
1.914 | 1.051-3.486 | 0.03 | 0.922 | 0.453-1.877 | 0.82 |
| Size (> 2cm vs ≤2cm) | 2.673 | 1.242-5.755 | 0.01 | 1.041 | 0.322-3.368 | 0.95 |
| Grade (G3 vs G1, G2) | 3.576 | 1.674-7.639 | 0.001 | 0.904 | 0.222-3.686 | 0.89 |
| Differentiation (NEC vs NET) | 4.401 | 2.240-8.645 | <0.001 | 4.713 | 1.345-16.516 | 0.02 |
| T stage (T3, T4 vs T1, T2) | 3.146 | 1.412-7.008 | 0.005 | 0.658 | 0.184-2.347 | 0.52 |
| N stage (N1 vs N0) | 3.634 | 1.125-11.742 | 0.03 | 2.458 | 0.699-8.644 | 0.16 |
| M stage (M1 vs M0) | 4.313 | 2.382-7.808 | <0.001 | 3.651 | 1.601-8.327 | 0.002 |
| Surgery (yes vs no) | 0.313 | 0.166-0.591 | <0.001 | 0.582 | 0.240-1.414 | 0.23 |
OS ,overall survival; NET, neuroendocrine tumor; NEC, neuroendocrine carcinoma; HR, hazards ratio; CI, confidence interval.