Figure 7.
PGC-1αPV−/− mice show reduced pyramidal firing rates, during preictal discharges compared with wild-type (WT) mice. Ai and Bi: the recording configuration for the underlying traces (as per Fig. 5 except recording action potentials in pyramidal cells). The blue traces indicate the action potential, cell-attached recordings from the PGC-1αPV−/− brain slices (note that the recorded cells actually express PGC-1α, as the knockout is specific to the PV interneurons). The underlying panels show preictal (Aii, Bii), and interictal (Aiii, Biii) pyramidal cell events. In each pair of recordings, the top traces show the cell-attached recording (gray) and the lower traces show the whole cell recording.