Table 2.
Ingenuity pathway analysis of the top biological functions regulated by TGFβ1 or combined inhibition of YAP and TAZ
| Biological Functions | Control vs. TGFβ1[−log10(P Value)] | TGFβ1 vs. YAP/TAZ[−log10(P Value)] |
|---|---|---|
| Cell movement | 24.7815 | 28.14746 |
| Migration of cells | 24.90333 | 27.43118 |
| Development of vasculature | 27.4003 | 23.92727 |
| Angiogenesis | 26.38825 | 23.45058 |
| Vasculogenesis | 26.94366 | 21.95053 |
| Growth of epithelial tissue | 21.91285 | 16.70681 |
| Organismal death | 24.26405 | 11.9369 |
| Morphology of body cavity | 19.33093 | 15.9761 |
| Development of body trunk | 16.16735 | 18.12851 |
| Abnormal morphology of body cavity | 19.37901 | 13.11802 |
IMR-90 cells were stimulated with TGFβ1 and treated with YAP/TAZ siRNA for 72 h. TAZ, transcriptional coactivator with PDZ-binding motif; TGFβ1, transforming growth factor β1; YAP, yes-associated protein.