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. 2022 Jan 3;434(6):167438. doi: 10.1016/j.jmb.2021.167438

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© 2021 Published by Elsevier Ltd.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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IFN-induced antiviral proteins inhibit distinct steps of CoV replication. Systematic genetic screens identified more than 30 ISGs that directly inhibit SARS-CoV-2 and/or HCoV-229E replication. The replication steps inhibited by some of these ISGs are illustrated.