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Domain structure and critical motifs of interferon-induced transmembrane (IFITM) proteins. (A) Membrane topology of IFITM proteins. (B) Domain structure of human and mouse IFITM proteins. NTD, N-terminal domain; CTD, C-terminal domain, Helix, amphipathic alpha helix; CIL, conserved intracellular loop; TMD, Transmembrane domain. CD225 domain contains amphipathic alpha helix and CIL domains. The oligomerization motif and cysteines for palmitoylation are indicated.
