Figure 4.

Viral loads from oropharyngeal swabs and respiratory tract tissues in SARS-CoV-2 SAM (LNP) vaccinated hamsters after challenge with SARS-CoV-2 virus

(A and B) Oropharyngeal swabs were taken from all hamsters on 1, 2, 3, and 7 dpi, and viral titers were determined by plaque assay. (C–E) Virus titers were determined in nasal turbinates (C), cranial right (D), and caudal right (E) lung lobes of four female and four male hamsters from each group at 3 dpi. Bars represent GMT+95% CI. Asterisks above bars indicate statistically significant difference in viral titers between mock and vaccine groups (∗∗∗∗, p < 0.0001; ∗∗∗, p < 0.001). Horizontal dotted line denotes limit of detection.