Table 3.

Increase scale of the four-step series to molnupiravir.

Step	Scale	% Corrected isolated yield	Area % HPLC (260 nm)	Wt % by NMR
1	100 g	94%	99.1%	95%
	300 g	92%	99.2%	95.5%
2	150 g	92%	98.6%	89%
	140 g	95.2%	94%	85.8%
3	130 g	70%	97.3%	94%
	120 g	76%	98.7%	95%
4	80 g	59%	98.6%	98.5%
	100 g	61%	99.6%	97.6%