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. 2022 Jan 3;22:23. doi: 10.1186/s12885-021-09080-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Kaplan–Meier curves showing the combined effects of (A) perilobular and intralobular fibrosis and (B) perilobular and intralobular fibrosis, acinar atrophy and chronic inflammation. A The overall log-rank (p = 0.001), between no fibrosis and peri- and intralobular fibrosis (p < 0.001) and between perilobular fibrosis and perilobular and intralobular fibrosis (p = 0.072). B The overall log-rank (p = 0.001), a comparison between no fibrosis, acinar athropy or chronic inflammation versus peri- or intralobular fibrosis (p = 0.914), versus fibrosis and atrophy (p = 0.001) or versus fibrosis, acinar atrophy and chronic inflammation (p = 0.001). We used the Bonferroni correction for multiple comparisons, with the decision level set to at p < 0.025 in A and p < 0.017 in B