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. 2022 Jan 3;20:3. doi: 10.1186/s12967-021-03205-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Individual estimates about the causal effect of serum 25OHD levels on MS. The x-axis shows the SNP (single nucleotide polymorphism) effect and SE (standard error) on each of the 20 serum 25OHD SNPs from 25OHD GWAS dataset (https://gwas.mrcieu.ac.uk/datasets/ebi-a-GCST90000615/). The y-axis shows the SNP effect and SE on multiple sclerosis (MS) from MS GWAS dataset (https://gwas.mrcieu.ac.uk/datasets/ieu-a-1025/). The regression lines for the MR-egger, weighted median, inverse variance weighted (multiplicative random effects), simple mode, weighted mode method are shown