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. 2022 Jan 3;10:1. doi: 10.1186/s40478-021-01305-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlation between MMP9 plasma level and neuro-radiological characteristic. A Illustrative magnetic resonance imaging (MRI) showing (from left to right): T1 sequence with contrast enhancement, FLAIR sequence, perfusion sequence and perfusion curve. Round mark: Region Of Interest (ROI) in enhanced tumor (right) and controlateral brain (left, control). B Neuro-radiological characteristics of peri-operative cohort. C T1 volume according to MMP9 plasma level. D FLAIR volume according to MMP9 plasma level. E Infiltrative pattern of glioblastoma (using the FLAIR/T1 volume ratio) according to MMP9 plasma level. F Corrected CBV ratio according to MMP9 plasma level. G Permeability coefficient according to MMP9 plasma level. No significant difference was shown