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. 2022 Jan 3;10:1. doi: 10.1186/s40478-021-01305-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — MMP9 is mainly expressed by tumor-infiltrating CD16 + neutrophils. A Frequency of immune subsets into the CD45+ cells. B T-SNE representation of immune subset in an illustrative case. C MMP9 expression: delta (d) Mean Fluorescence Intensity (MFI) [MFI mmp9—MFI fluorescence minus one (fmo)] in each immune subset. D MMP9 mean fluorescence intensity (MFI) shift between stained and unstained neutrophils (left) and inflammatory dendritic cells (right). E Percent of positive neutrophils (present in all cases) and inflammatory dendritic cells (present in only 3/5 cases) for MMP9. F T-SNE representation of the markers including MMP9 in an illustrative case. G Normalized expression of MMP9 based on CD45+ cell frequency and dMFI [%CD45*dFMI]