Table 11.

Estimates from segmented linear regression for adverse events in Site 4

Outcome	Estimate, ß (95% CI)	P Value	Interpretation
Adverse events
Intercept	29.69 (26.89, 32.49)
Pre-intervention trend	−0.10 (−0.40, 0.21)	0.55	There was no apparent significant trend in the overall adverse event rate.
Change in slope (implementation phase vs pre-intervention phase)	−0.64 (−1.15, − 0.13)	0.02	There was a significant deviation in the event rate during the implementation phase which probably represents a real clinical impact.
Immediate change in level (implementation period vs. pre-intervention period)	1.57 (−4.05, 7.18)	0.59
Change in slope (post-intervention phase vs implementation phase)	0.32 (−0.29, 0.93)	0.31	This trend was maintained but was not significantly different from the implementation phase.
Immediate change in level (post-intervention period vs. implementation period)	0.32 (−0.29, 0.93)	0.31