Figure 6.

Local associations of recent/acute microinfarcts with Aβ positive cortical vessels.

Based on the H&E-stained serial sections (A) from the third additional sample taken from the parieto-occipital cortex in one CAA case, 11 recent/acute microinfarcts (A’) were included. Lesions were localized on the adjacent Aβ-stained sections (B) to perform Sholl analysis (B’, inner circle with solid outline indicates masked area, circles with dotted outlines indicate first two shells). Significantly more Aβ positive cortical vessels were observed in the first shell immediately adjacent to a microinfarct compared to a simulated control lesion (p=0.031) (C). Scale bar in A and B = 5 mm, scale bar in A’ = 250 μm, scale bar in B’ = 500 μm. Error bars in C = SEM.