Table 1.
Case characteristics and ex vivo MRI and neuropathological findings.
| Case ID / sex / hemisphere | Age at death (years) / death due to acute ICH | PMI (hours) | CMBs on ex vivo 3T MRI / CMIs on ex vivo 3T MRI | CAA severity (cum score)* | Other neuropathological observations# |
|---|---|---|---|---|---|
| 1 / M / R | 80 / N | Unk | 41 / 115 | 5 | A3B3C2 |
| 2 / M / L | 70 / Y | 16 | 261 / 33 | 9 | A3B3C1, moderate hypertensive vasculopathy |
| 3 / M / R | 76 / N | 27 | 39 / 21 | 7 | A3B3C2, arteriolosclerosis |
| 4 / M / L | 65 / Y | 14 | 85 / 144 | 7 | A3B1C2 |
| 5 / M / R | 81 / N | Unk | 4 / 12 | 5 | A3B2C2, moderate arteriolosclerosis |
| 6 / F / L | 70 / n/a | Unk | 13 / 7 | 6 | n/a |
| 7 / M / L | 67 / N | Unk | 109 / 10 | 10 | A3B3C2 |
| 8 / M / L | 69 / Y | 36 | 4 / 5 | 10 | A3B1C2, mild arteriolosclerosis |
| 9 / F / R | 64 / Y | 30 | 161 / 3 | 8 | A3B2C3 |
| 10 / F / R | 79 / Y | 37 | 204 / 31 | 8 | A3B3C2 |
| 11 / M / L | 67 / N | 24 | 55 / 27 | 5 | A3B1C1, moderate arteriolosclerosis |
| 12 / F / L | 88 / Y | 11 | 192 / 64 | 8 | A2B3C2 |
CAA severity was evaluated on the Aβ-stained sections from the pre-defined standard areas of frontal, temporal, parietal, and occipital cortex using a 4-point scale; absent (0), scant Aβ deposition (1), some circumferential Aβ (2), widespread circumferential Aβ (3), following proposed consensus criteria13. Scores from the four areas were added to form a cumulative CAA severity score.
Extracted from neuropathology reports, based on routine neuropathological examination. ABC score reflects the NIA-Alzheimer Association score for Alzheimer’s Disease neuropathologic changes36.
ICH: intracerebral hemorrhage, PMI: post-mortem interval, CMBs: cerebral microbleeds, CMIs: cerebral microinfarcts, CAA: cerebral amyloid angiopathy, M: male, F: female