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. 2022 Jan 3;20:7. doi: 10.1186/s12967-021-03211-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Upregulation of Neat1 in the left ventricular tissue of mice after TAC surgery. A Representative PSR staining results were presented and quantified to demonstrate the extent of cardiac fibrosis (n = 6 in each group). B Representative M-mode images of TAC and sham group mice and quantification of EF% via echocardiography (n = 6 in each group). C Representative immunofluorescence images and quantitative data for Neat1 expression in the left ventricles (n = 8 in the sham group and n = 10 in the TAC group; red, Neat1; green, vimentin; blue, DAPI; scale bar = 50 µm). D Expression of Neat1 according to qRT-PCR results in the sham group or TAC group (n = 6 in each group). E Expression of Neat1 in PBS-treated CFs or TGF-β1-treated CFs (n = 6 in each group). Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001 for differences between the indicated groups