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. 2022 Jan 3;20:7. doi: 10.1186/s12967-021-03211-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Alleviation of TAC-induced cardiac fibrosis by AAV9-shNeat1. A Schema of the procedure for injection of AAV9 carrying shNeat1. B The silencing efficiency of AAV9-shNeat1 was verified by q-PCR (n = 6 in each group). C Representative results of picrosirius red staining of heart tissues obtained from the indicated groups (n = 7 in each group). D Representative immunofluorescence images of collagen I expression in the left ventricular tissue of the indicated groups (n = 7 in each group; scale bar = 100 µm). E Representative M-mode images of the indicated groups and EF% quantified by echocardiography (n = 8 in each group). F, G Representative western blot and quantitative analysis of cardiac fibrosis and Smad7 pathway-related proteins in left ventricular tissues from the indicated groups (n = 6 in each group). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, NS = no significant difference between the indicated groups