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. 2022 Jan 3;20:7. doi: 10.1186/s12967-021-03211-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Schematic model of Neat1 regulation of cardiac fibrosis. Neat1 recruits EZH2 to bind to the promoter region of Smad7, thereby inhibiting the expression of Smad7. This leads to the activation of p-Smad2/3, causing the activation of fibroblasts and ECM and ultimately leading to cardiac fibrosis