Table 1.
Demographic and baseline characteristics of study participants by sICH per mSITS-MOST criteria
| Variables | sICH (n = 33) | No sICH (n = 1260) | P-value |
|---|---|---|---|
| Age (years) | 65 (61–72) | 64 (55–71) | 0.153a |
| Sex, % | |||
| Male | 21 (63.6) | 824 (65.4) | 0.854 |
| Female | 12 (36.4) | 436 (34.6) | |
| DNT (min) | 66 (55–95) | 50 (35–69) | < 0.001a |
| Onset-to-needle time (ONT) (min) | 182 (143–215) | 171 (140–195) | 0.267a |
| Baseline NIHSS | 14 (10–18) | 7 (4–12) | < 0.001a |
| Hypertension, n (%) | 19 (57.6) | 734 (58.3) | 1.000 |
| Diabetes mellitus, n (%) | 7 (21.2) | 198 (15.7) | 0.466 |
| Dyslipidemia, n (%) | 1 (3.0) | 26 (2.1) | 0.506 |
| Coronary heart disease, n (%) | 12 (36.4) | 172 (13.7) | 0.001 |
| Atrial fibrillation, n (%) | 6 (18.2) | 89 (7.1) | 0.060 |
| Systolic blood pressure before thrombolysis, mm Hg | 151 (145.5–155) | 151 (140–164) | 0.610a |
| Diastolic blood pressure before thrombolysis, mm Hg | 86 (83–95) | 86 (80–94) | 0.210a |
| Smoking, n (%) | 11 (33.3) | 445 (35.3) | 0.856 |
| Alcohol consumption, n (%) | 11 (33.3) | 397 (31.5) | 0.850 |
| Blood glucose on admission (mmol/L) | 9.1 (5.9–12.3) | 8.3 (5.2–11.4) | 0.045a |
| Antiplatelet treatment pre-IVT, n (%) | 7 (21.2) | 146 (11.6) | 0.178 |
| Anticoagulant treatment pre-IVT, n (%) | 1 (3.0) | 19 (1.5) | 0.244 |
| Neutrophils ratio (%)b | 73.4 (63.2–81.4) | 67.2 (61.0–73.0) | 0.006a |
| Platelet count (× 1000/mm3) | 195.0 (170.3–231.5) | 223.3 (192.0–248.0) | 0.059a |
| White blood cell (×1000/mm3) | 9.0 (7.3–10.9) | 7.95 (6.03–8.40) | 0.004a |
| LDL-C, mmol/L | 2.89 (2.38–2.99) | 2.97 (2.53–3.33) | 0.155a |
| Use of thrombolysis medications, n (%) | |||
| rtPA | 26 (78.8) | 1070 (84.9) | 0.227 |
| urokinase | 7 (21.2) | 190 (15.1) | |
| Dose of rt-PA | |||
| No use | 7 (21.2) | 190 (15.1) | < 0.001 |
| 0.9 mg/kg | 26 (78.8) | 602 (47.8) | |
| 0.6 mg/kg | 0 (0) | 22 (1.7) | |
| 50 mg/person | 0 (0) | 446 (35.4) | |
| Dose of urokinase, n (%) | |||
| No use | 26 (78.8) | 1070 (84.9) | 0.281 |
| 1 million units | 6 (18.2) | 173 (13.7) | |
| 1.5 million units | 1 (3.0) | 17 (1.3) | |
| Stroke subtype, % | |||
| Atherothrombotic | 18 (54.5) | 972 (77.1) | < 0.001 |
| Small vessel disease | 3 (9.1) | 205 (16.3) | |
| Cardioembolism | 10 (30.3) | 60 (4.8) | |
| Unknown or other etiology | 2 (6.1) | 23 (1.8) | |
aStatistical significance, according to a Mann-Whitney U-test
bProportion (%) of neutrophils in the WBC