Table 3.
Multivariate analysis for EFS and OS among pediatric patients with B-ALL.
| Outcome | Variable | HR (95% CI) | P value |
|---|---|---|---|
| EFS | SCCLG-ALL-2016 Protocol | 0.5 (0.3, 0.8) | 0.001 |
| Age ≥10y or <1y | 2.0 (1.3, 3.2) | 0.002 | |
| WBC ≥50×109/L | 2.0 (1.1, 3.4) | 0.016 | |
| HR | 2.2 (1.0, 4.9) | 0.051 | |
| MLL-r(+) | 1.6 (0.7, 3.7) | 0.258 | |
| ETV6/RUNX1(+) | 0.7 (0.4, 1.2) | 0.194 | |
| PPR | 0.8 (0.4, 1.5) | 0.486 | |
| D15 BM | 1.4 (0.9, 2.3) | 0.181 | |
| D33 BM | 0.7 (0.2, 2.4) | 0.609 | |
| D15 MRD | 1.1 (0.7, 1.8) | 0.694 | |
| D33 MRD | 0.9 (0.5, 1.5) | 0.636 | |
| OS | SCCLG-ALL-2016 Protocol | 0.6 (0.3, 1.1) | 0.124 |
| Age ≥10y or <1y | 2.0 (1.1, 3.7) | 0.026 | |
| WBC ≥50×109/L | 1.6 (0.7, 3.4) | 0.235 | |
| HR | 2.8 (0.8, 9.5) | 0.098 | |
| MLL-r(+) | 3.0 (1.0, 8.7) | 0.042 | |
| ETV6/RUNX1(+) | 0.9 (0.4, 1.9) | 0.733 | |
| PPR | 1.8 (0.8, 4.2) | 0.147 | |
| D15 BM | 1.5 (0.8, 3.0) | 0.197 | |
| D33 BM | 1.5 (0.4, 5.3) | 0.553 | |
| D15 MRD | 1.1 (0.5, 2.1) | 0.858 | |
| D33 MRD | 0.9 (0.5, 1.9) | 0.843 |
WBC, white blood cell counts; HR, high risk; PPR, prednisone poor responders; MLL-r, MLL rearrangement; BM, bone marrow; MRD, minimal residual disease.